Following his run on "Project Runway," in 2007, Mychael Knight introduced his self-named label on BET's "Rip the Runway" (per Obvious Magazine). In 2008, he launched a lingerie line for both men and women, called Kitty & Dick. Knight's career included designing custom tees for Starbucks, launching his fall-winter line in 2010, and launching and ralaunching a second line called MYKA. According to an interview with Ebony, he was working on a dress line a few months before his death in October 2017. He's worked with a variety of celebrity clients such as Sherri Shepherd, Keri Hilson, Toni Braxton, Ciara, Keke Palmer, Jessica White, Claire Sulmers, and more.

Mychael Knight was just 39 years old when he passed away in 2017. The family did not release his cause of death, but the designer had been open with the public about his struggle with intestinal issues. He had been struggling with irritable bowel syndrome (IBS) for about five years and suffered from symptoms such as abdominal pain and extreme fatigue. After the announcement of his death, celebrities shared pictures of themselves wearing his creations to honor Knight and his legacy (per People).

Knight's friend Jerris Madison published a piece reflecting on his friendship with Knight in Obvious Magazine. Madison described Knight as being a "mama's boy" and a "passionate, outspoke, direct, kind, and unapologetic" artist.