While Meghan McCain seemed to like Kamala Harris back in 2019, by 2021, things had soured. In her column for The Daily Mail, McCain stated, in no uncertain terms, that Harris was "failing to rise to the occasion and the opportunity of her office," which, at the time, was the office of the Vice Presidency. 

McCain even went so far as to say in her piece for The Daily Mail that a New York Times article which had reported Harris privately confiding to her allies that "the news coverage of her would be different if she were any of her 48 predecessors, all of whom were white and male" made McCain "almost spit out [her] coffee" due to the ludicrousness of the claim. Instead, McCain argued that it was precisely her gender and ethnicity that had given Harris a leg up when running on the Democratic ticket with Joe Biden.  

Also in 2021, McCain took offense to a tribute that Harris paid to Meghan's father, the late Senator John McCain. At the time, Harris had gone to the cemetery where John McCain is interred to pay her respects on the third anniversary of the war hero's passing. But Meghan wasn't impressed, tweeting, "If you want to honor my dads legacy on this anniversary of his death — you would spend every second making sure every single American and Afghan ally is out of harms way," referring to the American military's exit from Afghanistan.