Vannessa Cross and Meghan Crumpler have previously discussed their shared weight loss journey in another show. As The Cinemaholic reported, Cross and Crumpler starred in the first episode of the first season of Discovery+'s "Too Large," a show similar to "My 600-lb Life" that showcases weight loss struggles experienced by a new person (or people) on their way to receiving bariatric surgery each episode. Cross and Crumpler's episode premiered in 2021. While on the show, Cross, who was relying on a food pantry to receive her food, struggled to lose enough weight to qualify for bariatric surgery while her friend, Crumpler, managed to lose around 40 pounds by the end of the friends' episode — which was more than enough to qualify for the weight loss surgery that both women wanted to receive.

In "1,000-Lb. Best Friends," Cross hopes to finally receive that weight loss surgery. "Meghan got the surgery and I didn't, but maintaining my diet has been damn near impossible but I'm sick and tired of being fat and tired," Cross said in a preview clip of the show, per E! News. There will also be plenty of opportunities for laughs on the new show, as the Cross, Crumpler, and their friends Ashely Sutton and Tina Arnold go on fun-filled camping trips, outrageous exercise classes, and other adventures.