In his younger years, "Days of Our Lives" viewers watched Mike Horton fall hard for a woman named Trish Clayton (via Soaps in Depth). The couple even got engaged, but they never made it down the aisle. Mike moved on to have a quick fling with Linda Patterson before falling head over heels for Margo Anderman. The couple married, but sadly, Mike and Margo's time was marked with tragedy after she was diagnosed with leukemia. Margo's treatments left the couple in tons of financial debt and after Margo died, Mike found the inspiration to go to medical school and become a doctor like many of his Horton family members before him.

Mike left Salem and when he returned as a doctor he began working at Salem University Hospital, where he met Robin Jacobs. The couple fell deep for each other, but their religious beliefs kept them from tying the knot, per Soap Central. Robin ultimately married another man and Mike moved on to have relationships with women such as Janice Barnes and Gabrielle Pascal. However, those romances weren't the right fit for Mike, who remained unable to find true love until he met a woman named April Ramirez.

Mike (then played by Michael T. Weiss) and April (Lisa Howard) seemed like they were meant to be and they quickly began dating. Soon after, Mike popped the question and the pair celebrated their engagement. However, they never got their happy ending.